An analysis in steatotic, NASH, and HCC mice revealed 10 differentially expressed miRNAs in NASH and HCC with respect to the controls, including miR-107-3p, miR-221-3p, miR-222-3p, and miR-223-3p, that are involved in major liver carcinogenesis-related pathways, e.g., cell cycle regulation, stem cell regulation, epithelial–mesenchymal transition (EMT), TGF-β, STAT3, Wnt/β-catenin, ERK/MAPK, PPARα/RXRα, PTEN, mTOR, and NF-κB signaling [34]. This evidence concerns the gene PTEN and hepatocellular carcinoma.