Notably, five of the brain onco-driver genes (enolase 1 (Eno1), mucin 1 (Muc1), collagen type V alpha 1 chain [Col5a1], collagen type V alpha 1 chain (Col11a1), and interleukin 11 (Il11)) (Table 1), and two of the non-brain onco-driver genes (absent in melanoma 2 (Aim2) and Jun B proto-oncogene (Junb)) have been reported to regulate tumor immunosurveillance and therapy responses [35,36] (Figure 1D, Dataset S1). The gene discussed is IL11; the disease is neoplasm.