AKT1 and cancer: Interestingly, notable DGEn was observed for eight terms linked to cancer out of the top 20 terms (lowest FDRs) identified, including pathways in cancer, hepatocellular carcinoma (HCC), microRNAs in cancer, and proteoglycans in cancer, as well as terms for the Hippo, ras-proximate-1 (RAP1), mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)-AKT signaling pathways (Figure S4B,C).