In line with growing evidence indicating a nuclear transactivational function for FABP7 in normal glia and glioma cells, our unbiased analysis of large-scale transcriptomic data—combined with the analysis of LGG and GBM patient tumors and outcomes—revealed that FABP7 regulates multiple onco-immune drivers to foster immunosuppressive environments within tumors, collectively impacting prognosis and survival. This evidence concerns the gene FABP7 and glioma.