CD34-positive cells derived from CML patients have a higher expression of ATG4B, an autophagy-related gene, than normal bone marrow CD34-positive cells, and the suppression of autophagy by the knockdown of ATG4B resulted in decreased cell proliferative capacity and colony-forming ability [140]. This evidence concerns the gene CD34 and chronic myelogenous leukemia, BCR-ABL1 positive.