Research has shown that alpha-fetoprotein secreted by hepatocellular carcinoma cells can inhibit the normal immune function of DCs by suppressing their FAS activity through the inhibition of sterol regulatory element-binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α) in DCs [113]. The gene discussed is PPARGC1A; the disease is hepatocellular carcinoma.