In liver cancer, tumor cells promote the recruitment and expansion of MDSCs within the TIME by releasing hypoxia-inducible factor 1-alpha (HIF-1α) and tumor-associated cytokines, such as IL-6, IL-1β, GM-CSF, G-CSF, VEGF, MCP-1, and MIF [123,124]. The gene discussed is HIF1A; the disease is neoplasm.