The relationship we observed between rs 11077/XPO5 and depression may be due to the fact that miRNA-related single-nucleotide polymorphisms (miR-SNPs), which are defined as single-nucleotide polymorphisms (SNPs) in miRNA genes, the miRNA binding site, and the miRNA-processing mechanism can modulate miRNA and target gene expression. The gene discussed is XPO5; the disease is major depressive disorder.