TNF and age: Age-related inflammation, called inflammaging, is characterized by increased levels of circulating C-reactive protein (CRP), as well as pro-inflammatory cytokines, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, IL-13, IL-15, IL-18, IL-22, IL-23, tumor necrosis factor (TNFα), and interferon (IFNγ) [27].