As recently demonstrated, the metalloprotease ADAM17 contributed to the release of ephrin-A1 from the cell surface of non-small-cell-lung (NSCL) cancer cells, thereby enhancing EphA2-S897 phosphorylation, and ADAM17 activity was associated with enhanced in vitro cancer cell migration and resistance to ionizing radiation [38]. The gene discussed is EFNA1; the disease is cancer.