EPHA2 and cancer: The notion that EphA2 plays a pivotal role in driving the progression of multiple cancers is also supported by a recent in silico pan-cancer study that used TCGA, GTEx, and CPTAC databases and analyzed EphA2 expression, tumor mutation, and DNA methylation status in normal versus tumor tissues as well as the association between EphA2 and clinical stage and prognosis in different tumors [46].