Noncanonical EphA2 signaling is oncogenic and characterized by serine 897 (S897) phosphorylation modulated by three major signaling pathways: cAMP/PKA, AKT/mTORC1, and MAPK/RSK [11,49,50], and is associated with enhanced migratory and invasive capabilities of tumor cells as well as stemness and chemoresistance [51,52] (Figure 1A). Here, AKT1 is linked to neoplasm.