Further data from our group revealed an up-regulation of C16-ceramide and S1P in the serum of HCC patients and proposed in this way a role of SLs as potential serum biomarkers of HCC [22] while serum C16-ceramide was able to independently predict de novo HCC in cirrhotic patients after the successful eradication of HCV [23]. Here, MBTPS1 is linked to hepatocellular carcinoma.