The exact mechanisms by which mt-hOGG1 protects against HFD-induced insulin resistance are unclear, however, based on the results of oxidative mtDNA damage analysis, we can propose that the OGG1 BER enzyme activity is involved since mt-hOGG1 prevented liver oxidative mtDNA damage in Ogg1-KO/Tg mice (Figure 4A). This evidence concerns the gene OGG1 and Insulin resistance.