Taking these observations together and considering that mitochondrial metabolism function plays an important role in insulin signaling and insulin resistance, we speculate that mt-hOGG1 promotes mitochondrial well-being and quality, thus leading to the observed improved insulin signaling in the liver of HFD-fed Ogg1-KO/Tg mice (Figure 5A, quantified in Supplementary Figure S6A). This evidence concerns the gene INS and Insulin resistance.