This divergence in the machinery of NFκB activation between healthy and preeclampsia-complicated gestations may exist, as more recent studies suggest that the launching pathway of NFκB activation characteristic for placental cells living in the preeclamptic environment is driven by the tumor protein p53/ribosomal protein S6 kinase alpha-1 (p53/RSK1) complex [13]. This evidence concerns the gene TP53 and preeclampsia.