The activation of this specific preeclampsia mechanism of the activation of NFκB might result in the dysregulation of two other molecular pathways in preeclamptic placentas, i.e., phosphatidylinositide 3-kinase protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), known as the ERK1/ERK2 pathway. The gene discussed is MAPK3; the disease is preeclampsia.