The JAK/STAT3 pathway works closely with leukemia inhibitory factor (LIF) to induce inflammation and endothelial dysfunction, characterized by increased levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), all of which are hallmarks of preeclampsia [87]. The gene discussed is VCAM1; the disease is preeclampsia.