In addition, a 5-year survival analysis further confirmed the absence of a significant association between CIS link proportions and survival (Figure 5), with p-values remaining non-significant across all subtypes (Luminal A: p = 0.8; Luminal B: p = 0.74; Her2: p = 0.47; Basal: p = 0.18). The gene discussed is ERBB2; the disease is in situ carcinoma.