On the other hand, AKT activation through integrin αvβ3 has been widely demonstrated in prostate and lung cancer among others [97,98,99], as well as PI3K/AKT activation by PKC [100,101,102] and THs-induced PKC activation through the mTR [47] integrin αvβ3 [43]. The gene discussed is AKT1; the disease is lung carcinoma.