Interestingly, treatment with 10 nM of progesterone significantly improves brain resilience under neuropathological conditions by enhancing progesterone receptors, especially the expression of progesterone receptor membrane component 1 (PGRMC1) of non-genomic signaling pathways, thus mediating the neuroprotective effects in the ENS in neuronal cells and experimental PD models [242]. The gene discussed is PGRMC1; the disease is Parkinson disease.