Finally, treatment with the probiotic Komagataella pastoris KM71H (8 log UFC·g−1/animal, intragastric route) prevented restriction stress-induced depression-like behaviors and LPS challenges by regulating BBB permeability, attenuating proinflammatory NF-κB, IL-1β and IFγ cytokines and indoleamine 2,3-dioxygenase levels in the hippocampus, prefrontal cortex and intestine, mediated by the depletion of plasma corticosterone levels, in mice [186]. The gene discussed is IL1B; the disease is major depressive disorder.