A recent study has demonstrated that a synergistic treatment, combining glutamine, Curcuméga® (a food supplement containing curcumin and polyunsaturated n-3 fatty acids) and Gabolysat® (bioactive peptides from a fish hydrolysate) reduces colonic hyperpermeability and inflammatory markers (CXCL1, TNFα and IL1β) in murine models of irritable bowel syndrome (IBS) more effectively than each compound alone [80]. The gene discussed is TNF; the disease is irritable bowel syndrome.