RHOA and colorectal carcinoma: LRRFIP1, that regulates a wide range of biological processes, such as immune response, cytoskeletal remodeling, signal transduction, and transcriptional regulations of genes (including regulation of EMT) in the case of CRC, via regulation of RhoA-induced cell adhesion, migration, and invasion, plays an important role in metastasis to the liver [44,45,46].