For instance, papiliocin, an insect cecropin recognized as an anti-endotoxin AMP, alleviates the impact of E. coli-induced sepsis and exhibits immunomodulatory effects by inhibiting the TLR4-NFκB signaling pathway through competitive interference with the LPS-TLR4/MD-2 interaction [35]. Here, NFKB1 is linked to Sepsis.