Moreover, we found that the expression of a distinct group of INVS-interacting factors, including NPHP3, DVL1, DVL3, and ANKS6, is strongly predictive in terms of the overall and/or disease-specific survival length of ccRCC patients, making INVS and this distinguished interactome group potentially clinically useful prognostic indicators. This evidence concerns the gene INVS and nonpapillary renal cell carcinoma.