The aim of this study was to explore the prognostic potential of INVS expression in ccRCC, its relation to metastasis occurrence, and its potential mechanisms in ccRCC pathogenesis, as well as its role as a potential therapeutic target in ccRCC The results of this study show that the INVS expression decreases in ccRCC tissue in comparison to normal renal tissue and that its lower expression is related to the poorer overall and disease-specific survival of patients and a shorter progression-free interval. The gene discussed is INVS; the disease is nonpapillary renal cell carcinoma.