INVS and neoplasm: In order to reveal the mechanism of INVS and its interactome effects on ccRCC pathogenesis and the clinical outcome, we explored the correlation of INVS and its partners with tumor leukocyte infiltration (Figure 6 and Figure 7; Supplementary Figures S8–S10) and the expression of immune checkpoint inhibitors, by using TISIDB [26] and GEPIA [27] portals (Figure 8; Supplementary Figures S11 and S12).