SOCS3 and type 2 diabetes mellitus: Although our study suggests that SOCS3 may affect T2DM induced by exposure to TCS, due to the lack of corresponding toxicological experiments and metabolomics studies, we are unable to conclusively state that TCS can prevent insulin signaling and ultimately induce the development of T2DM.by increasing the level of IL-6 and affecting the methylation of SOCS3.