MYC, located on chromosome 8q24.21, is overexpressed in up to 45% of solid tumors [5] and translocated in up to 15% of diffuse large B-cell lymphomas (DLBCL) [6] and multiple myeloma (MM) [7] patients, and in 95–100% of all Burkitt lymphoma (BL) patients [8,9]. Here, MYC is linked to AL amyloidosis.