EPHA2 was found to promote the formation of vasculogenic mimicry (VM) in colorectal cancer (CRC) via PI3K/AKT/mTOR and ERK1/2 signaling [38], and TNF plays a role in angiogenesis by synergistically inducing VEGF production with IL-1beta (IL1B). This evidence concerns the gene AKT1 and colorectal cancer.