CD177 and irritable bowel syndrome: Furthermore, we analyzed the expression of genes involved in the Toll-like receptors (TLR)s cascade pathways to highlight any differences among the four experimental cohorts, as TLRs are cell surface receptors considered to play a critical role in triggering innate immune responses by recognizing and binding to molecules present on microbes’ cell walls [24], hence affecting several aspects of IBD pathogenesis [25].