These studies identified an obesity-related single-nucleotide polymorphism (SNP), rs10938397, near to the GNPDA2 gene, which is associated with an increased body mass index and obesity; in fact, the relationship of GNPDA2 with type 2 diabetes and asthma is mediated through obesity. Here, GNPDA2 is linked to obesity due to melanocortin 4 receptor deficiency.