Ontologies such as response and defense against viruses, antimicrobial humoral immune responses mediated by antimicrobial peptides, and the regulation of myoblast fusion were associated with 20 genes in the Trisomy 21 with CHDs datasets (GSE196443 and GSE217557), including GNLY, IFI44L, and CXCL9 (Figure S2c). Here, IFI44L is linked to trisomy 21.