One of our model cell lines (HCT-15) was derived from colorectal cancer and harbors the KRAS mutation in addition to mutations in the APC, B2M, CHEK2, BRCA2, PIK3CA, and TP53 genes [“https://www.cellosaurus.org/CVCL_0292 (accessed on 21 December 2021)”]. The gene discussed is B2M; the disease is colorectal cancer.