MOG-induced experimental autoimmune encephalomyelitis in C57BL/6 mice is a typical animal model of MS to display a chronic-progressive clinical course with T and B cell responses [40,41], while MOG-induced primary progressive EAE in NOD mice has been reported to develop neuroimmunological characterization that mimics progressive MS patients [42]. Here, MOG is linked to experimental autoimmune encephalomyelitis.