In addition to variations in the RyR2 gene, other, less common genetic modifications associated with CPVT have been identified, involving genes such as TRDN (603283), the calmodulin gene family CALM1 (114180), CALM2 (114182), and CALM3 (114183), ANK2 (106410), and TECRL (617242) [69]. The gene discussed is ANK2; the disease is catecholaminergic polymorphic ventricular tachycardia.