MYC and osteosarcoma: Kuijjer et al. analyzed MYC expression in OS patients with the R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) using the Mixed Osteosarcoma-Kuijjer dataset [62] and demonstrated that it was significantly up-regulated in the metastatic samples, suggesting a possible role in the promotion of OS metastasization [63].