The study on human GBM (glioblastoma multiforme) cell line U87-MG found that caffeine increased the TMZ’s (Temozolomide, a first-line chemotherapeutic agent used to treat the glioblastoma multiforme) chemo-efficacy by inhibiting the ATM/p53/p21 pathway and the promoting mitotic catastrophe [164]. This evidence concerns the gene ATM and glioblastoma.