The hypomethylation of MMP2 and CTGF in dilated cardiomyopathy increased the expression of MMP2, a regulator of collagen turnover and fibrosis that is increased in patients with heart failure, and CTGF, which functions in extracellular matrix fibrosis and is highly expressed in failing hearts [6]. Here, CCN2 is linked to dilated cardiomyopathy.