Disease activity in RA is tracked using a set of composite measures alongside imaging such as the disease activity score utilising a 28-joint count (DAS-28) in which the clinician assesses the number of swollen and tender joints along with inflammatory markers; for example, erythrocyte sedimentation rate (ESR) or the C-reactive protein (CRP) and patient global assessment (PGA) of disease activity [6]. The gene discussed is CRP; the disease is rheumatoid arthritis.