In a prospective case–control study that included apparently healthy men, published in 1998, Ridker et al. found that the relative risk of developing PAD increases significantly with increasing CRP, so that men with CRP around 2.1 mg /L had a double risk compared to men with CRP around 0.55 mg/L and this result was independent of other risk factors such as DM, arterial hypertension, BMI, and family history of atherosclerotic diseases [27]. The gene discussed is CRP; the disease is diabetes mellitus.