GRIN2A and autism spectrum disorder: In general, GRIN2B dysfunction has been mostly associated with cognitive delay, autism spectrum disorder, schizophrenia, and behavioral abnormalities, while GRIN2A impairment has been mainly related to a more specific phenotype with predominant epilepsy, ranging from the common benign childhood epilepsy with centrotemporal spikes to the rarer Landau–Kleffner syndrome, but also speech delay and intellectual disability.