In general, GRIN2B dysfunction has been mostly associated with cognitive delay, autism spectrum disorder, schizophrenia, and behavioral abnormalities, while GRIN2A impairment has been mainly related to a more specific phenotype with predominant epilepsy, ranging from the common benign childhood epilepsy with centrotemporal spikes to the rarer Landau–Kleffner syndrome, but also speech delay and intellectual disability. This evidence concerns the gene GRIN2A and schizophrenia.