For instance, universal subunit vaccine candidate Multimeric-001 (M-001) contains nine B- and T-cell epitopes (CD4+ and CD8+) from NP, HA and M1 that are conserved in both influenza A and B. M-001 is believed to induce an influenza-specific cellular immune response that is crucial for providing protection [43]. This evidence concerns the gene CD4 and influenza.