Based on WGCNA mining, for the gene modules closely related to mRNAsi and subsequent ssGSEA analysis, we obtained 10 key genes related to immune cell infiltration in HCC, including CDC6, DTL, FOXM1, HJURP, KIFC1, MCM2, MELK, NEK2, PRC1, and TOP2A. This evidence concerns the gene MELK and hepatocellular carcinoma.