Rivipansel (GM1-1070), GlycoMimetics’ pan-Selectin inhibitor, is capable of binding to E-selectin, P-selectin, and L-selectin with micromolar affinity, therefore inhibiting leukocyte rolling and reversing vascular occlusion in a mouse model of sickle cell disease [289]. The gene discussed is SELP; the disease is sickle cell disease.