Haploinsufficiency was also possible with PSEN1 Trp294Ter in a patient with retinitis pigmentosa and acute encephalopathy [47], PSEN1 Ser357Ter in a patient with cognitive decline and cerebral amyloid angiopathy (CAA) [48], and PSEN1 Gly378fs in a Moroccan family with AD [49]. This evidence concerns the gene PSEN1 and Mental deterioration.