Interestingly, all of these genes have been linked to viral infections to some extent, including the key role of Birc5 and Plk1 in the survival of HIV-1- [47] and hepatitis B [48]-infected cells, respectively, the up-regulation of Cdca3 during dengue fever [49], and the hub position of Tpx2 in the COVID-19 regulome [50]. The gene discussed is PLK1; the disease is hepatitis B virus infection.