Given the ability of SPAG5 to control mTOR signaling by inhibiting mTOR–Raptor association and recruiting Raptor to stress granules [86], the overexpression of SPAG5 in severe COVID-19 may be a cytoprotective response that protects lung cells from death induced by SARS-CoV-2-mediated mTORC1 hyperactivation [87]. Here, SPAG5 is linked to COVID-19.