Thus, the obtained results, supported by data from available disease-related transcriptomic databases, clearly demonstrate that Birc5, Nusap1, Plk1, Prc1, Rrm2, Spag5, Top2a, and Tpx2, identified here as core genes of inflammation-to-metaplasia transition in IAV-infected lungs, are also involved in proliferation-related processes in a variety of severe lung diseases, which may indicate a master regulatory role of these genes in the development of IAV-induced severe lung failure, which requires further knockdown studies. This evidence concerns the gene TOP2A and lung disorder.