Additionally, overexpressed genes such as IKAROS family zinc finger 3 (IKZF3), MER proto-oncogene, tyrosine kinase (MERTK), and Fc receptor-like 5 (FCRL5) all have risk alleles associated with MS or other autoimmune diseases [14,15] (Figure 1A). The gene discussed is MERTK; the disease is autoimmune disease.