We explored the association of FOLR1 expression with the expression of genes encoding five other molecules involved in the folate/FRα signaling pathway in normal ovary and ovarian cancer tissues: MTHFR, methylene tetrahydrofolate reductase; FOLH1, glutamate carboxypeptidase; TYMS, thymidylate synthase; DHFR, dihydrofolate reductase; and SLC19A1 folate transporter 1. The gene discussed is MTHFR; the disease is ovarian cancer.