The researchers applied a non-negative matrix factorization (NMF) approach to extract differentially expressed gene (DEG) subgroups, identifying 241 candidate genes (such as actin beta (ACTB), serine incorporator 3 (SERINC3), and zinc finger MIZ-type containing 1 (ZMIZ1)) that share common features with AD and T2DM, such as dysregulated T cell selection and chemokine pathways. This evidence concerns the gene ACTB and type 2 diabetes mellitus.