PICALM and Alzheimer disease: Furthermore, genome-wide association studies (GWASs) have identified numerous other genes potentially associated with AD, including disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), ATP-binding cassette sub-family A member 7 (ABCA7), bridging Integrator 1 (BIN1), cortactin-CD2-associated protein (CD2AP), ephrin type-A receptor 1 (EPHA1), phosphatidylinositol binding clathrin assembly protein (PICALM), sortilin-related receptor 1 (SORL1), complement receptor type 1 (CR1), clusterin (CLU), microtubule-associated protein tau (MAPT), and others.