In this study, we showed that IGF-1 is overexpressed in high-grade serous carcinoma (HGSC) cell lines, specifically OVCAR3 cells, at both mRNA and protein levels, being a good cell line model to study the IGF-1 inhibition via knockdown of this gene by siRNA or IGF-1R inhibition with linsitinib. This evidence concerns the gene IGF1R and serous adenocarcinoma.