The analysis results showed that NEDD4L expression was positively correlated with many pathways, such as propanoate, fatty acid, butanoate, pyruvate, inositol phosphate metabolism, valine, leucine, isoleucine and lysine degradation, steroid biosynthesis and glycosylphosphatidylinositol/GPI anchor, peroxisome, citrate cycle/TCA, and PPAR signaling pathways, which were downregulated in ccRCC. Here, NEDD4L is linked to nonpapillary renal cell carcinoma.