CD8A and neoplasm: On the contrary, NEDD4L expression was positively correlated with naive B cells (p < 0.0001), M1 macrophages (p = 0.0033), and resting mast cells (p < 0.0001), and negatively correlated with the ratio of CD8+ T cells (p = 0.016), follicular helper T cells (p < 0.0001), Tregs (p < 0.0001), M0 macrophages (p < 0.0001), and activated mast cells (p = 0.0028), which have tumor-promoting effects (Figure 6B).