Interestingly, low expression of NEDD4L and high expression of RAC2 shared many similar tumor-associated pathways including immune regulation (cytokine–cytokine receptor interaction, primary immunodeficiency, antigen processing and presentation, T cell receptor signaling pathway, and leukocyte transendothelial migration), proteasome pathway, cell adhesion, cell cycle, Toll-like receptor signaling pathway, and JAK-STAT signaling pathway. Here, NEDD4L is linked to inborn error of immunity.