Online TCGA data analysis also confirmed the low expression of NEDD4L (Figure 3E,F) and high expression of RAC2 (Figure 3G,H) in ccRCC using TIMER 2.0 and GEPIA2, while the cBioPortal database further revealed the inverse correlation between RAC2 and NEDD4L expression (Figure 3I). This evidence concerns the gene NEDD4L and nonpapillary renal cell carcinoma.