As shown in Table 2, RAC2 expression was significantly positively correlated with grade (<0.001), TNM stage (p = 0.014), lymph node metastasis (p = 0.004), distant metastasis (p = 0.034), and vital status (p = 0.003), while NEDD4L expression was significantly negatively correlated with grade (<0.001), TNM stage (p < 0.001), invasive depth (p < 0.001), distant metastasis (p = 0.001), and vital status (p < 0.001) in ccRCC patients. This evidence concerns the gene NEDD4L and metastatic malignant neoplasm in the lymph nodes.