miR-133b binds to the 3′-UTR of PTBP1 and TAGLN2 mRNAs to regulate downstream targets, suggesting that its protective effect on cardiomyocyte apoptosis and myocardial fibrosis may occur through inhibiting PTBP1 and TAGLN2 expression [20]. The gene discussed is PTBP1; the disease is Myocardial fibrosis.