Covering the whole disease spectrum from MASLD to cirrhosis [5,6,7], CK-18 levels of elevation are also observed in diseases with increased cardiovascular (CV) risk, such as chronic kidney disease [8], type 2 diabetes (T2D) [9], and other conditions related to endoplasmic reticulum and oxidative stress [10,11]. The gene discussed is KRT18; the disease is type 2 diabetes mellitus.