APOE and metabolic dysfunction-associated steatohepatitis: While apoE−/− mice on a Western diet have proven to be a convenient model for advanced NASH/MASH [28,29], mice fed a choline-deficient, L-amino-acid-defined, high-fat diet (CDAHFD) are considered to be an earlier MASH model due to the absence of fibrosis within one week of the diet despite developing steatosis and steatohepatitis more rapidly and severely than conventional models [30].