TNFRSF1A and Dilatation of the cerebral artery: In a study conducted by Aoki et al. [15], it was highlighted that the NF-κB pathway can be activated by TNF-alpha, as evidenced by the fact that in TNFR-1 heterozygous and TNFR1-deficient mice, the incidence of intracranial aneurysms was reduced compared to wild-type mice [14].