AGER and Alzheimer disease: In addition, the expression of low-density lipoprotein receptor-associated protein 1 (LRP1) and P-glycoprotein (P-gp/ABCB1), the transporters that mediate Aβ outflow from the blood–brain barrier (BBB), are decreased in AD patients, and inversely, the expression of the receptor of advanced glycation end products (RAGE), a transporter that mediates the inflow of BBB, is increased, ultimately leading to Aβ deposition [28,29,30].