Among multiple studies, BDNF was recently found to be associated with sedentary patterns in patients with type 2 diabetes mellitus [112], and is currently being reviewed as inversely associated with such sedentary behaviours among children and adolescents [113], which makes the contribution of this paper with a model for an integrative framework a critically needed antidote for the modern environment to ensure the neurosustainability of the human brain [114]. The gene discussed is BDNF; the disease is diabetes mellitus.