MAPT and Alzheimer disease: The main neuropathological characteristics of the brain in AD are the appearance of extraneuronal amyloid deposits (plaques of different types and diffuse/microgranular amyloid) and intraneuronal deposits of other insoluble and non-degradable proteins (hyperphosphorylated tau protein, alpha-synuclein) that form accumulations of different sizes (from large “neurofibrillar tangles” to small deposits that distort dendrites and axons—“dystrophic neurites”).