Bury et al., 2021 [105], in a study on six cases of T2D with minimal AD neuropathology (Braak 0-II) and without confounding pathologies or dementia, found significant dysregulation of several key signaling pathways associated with T2D, the cell cycle, and cellular senescence and also of AD-related genes (amyloid vein precursor protein and neprilysin) and down-regulation of mitochondrial respiratory electron transport. This evidence concerns the gene MME and type 2 diabetes mellitus.