COMT and schizophrenia: Also, it is of note that the genetic combination pattern solely associated with SZ disease risk is composed of 10 SNPs, out of which only 4 are directly related to the dopaminergic system: DDC (rs2329371, rs1966839), SLC6A3 (DAT1) (rs11133767), and COMT (rs4646316), hinting at the probable multi-neurotransmitter imbalance pathogenesis of schizophrenia.