The Gold Coast criteria’s (GCC) requirements for ALS diagnosis are (1) a documented history or repeated clinical assessments that demonstrate progressive motor impairment after a period of normal motor function; (2) the presence of both upper and lower (clinical or EMG) motor neuron signs in at least one body region (or UMN and LMN dysfunction in the same body region if only one region is affected), or LMN dysfunction in at least two body regions; (3) thorough investigations must be conducted to rule out any other potential disease process (Table 1). This evidence concerns the gene LMNB1 and amyotrophic lateral sclerosis.