Two distinctive neuropathological markers characterize AD: neurofibrillary tangles (NFTs), which are made of hyperphosphorylated tau protein, and extracellular aggregates of amyloid-beta (Aβ) peptide, which accumulate in brain tissue to form neuritic plaques and in blood vessels to form cerebral amyloid angiopathy (CAA) [5]. The gene discussed is MAPT; the disease is Alzheimer disease.